We have decided to overcome the difficulty,___great it is.A)howeverB)whateverC)howD)whatP.S.该怎么区分这些词还有具体选项

We have decided to overcome the difficulty,___great it is.
A)however
B)whatever
C)how
D)what
P.S.该怎么区分这些词还有具体选项

选A)however
however=no matter how 无论怎样的……
whatever =no matter what 无论什么……
题中意思是无论困难有多么的大……