I don't know what/how/when to do with the problem选择的原因

I don't know what/how/when to do with the problem选择的原因

I don't know what to do with the problem
how 与deal with 连用;
what与do with 连用,记住喽

how 吧！表示怎么解决这些问题！

what.
任何语法学得好的人都不是学语法学出来的。

我不知道这个问题如何处理

I don't know what to do with the problem.