Drugs can be anything that changes the way your mind or boby works.此句的that能不能换成which.

Drugs can be anything that changes the way your mind or boby works.此句的that能不能换成which.

先行词是 all,much,little,everything,anything,nothing,none等代词时,只能用that.
例如：
① You should hand in all that you have.
② We haven’t got much that we can offer you.
此句的先行词是anything,故用that

不定代词(anything,something,nothing)之后只加that