His sister looks unhappy,___ ___?反意疑问句

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His sister looks unhappy,___ ___?反意疑问句

doesn't she?

doesn't she?

doesn't she?

当陈述句部分带有否定前缀的词时,此陈述句当作肯定句, 其后的附加部分用否定形式。
所以是 doesn‘t she。